Ozempic & Wegovy: Why You’re Losing Muscle, Not Just Fat

Ozempic & Wegovy: Why You’re Losing Muscle, Not Just Fat

March 21, 20254 min read

Are those miracle weight loss shots like Ozempic and Wegovy secretly stealing your strength? Imagine losing weight, but also your muscle, setting you up for unexpected knee pain and a future filled with weakness.

In this podcast episode, we're diving deep into the shocking truth about how these medications can trigger muscle loss, and why that's a bigger deal than you think. If you've noticed your joints aching or you're just not feeling as strong as you should, you need to hear this. I'll explain exactly how this happens, how it messes with your ability to move, and, most importantly, give you simple steps to protect your muscles and stay healthy.

Don't let weight loss cost you your strength and mobility. Dive in now to discover the vital information you need to keep your body strong and healthy!

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GLP-1 medications like Ozempic, Wegovy, and Mounjaro have been hailed as revolutionary for weight loss. But beyond the rapid fat reduction, there's a lesser-known consequence, muscle loss. Many people taking these medications experience a decrease in lean body mass, which can weaken joints, cause knee pain, and lead to long-term mobility issues. If you've heard of "Ozempic butt," you already know that fat isn't the only thing disappearing, critical muscle mass is also lost, which plays a crucial role in joint stability, movement, and metabolic health.

GLP-1 Medication and Muscle Loss: Understanding the Risks

Studies show that up to 40% of the weight lost with GLP-1 medications comes from lean body mass—which includes muscle, bone, and connective tissue. This is problematic because maintaining muscle strength is essential for overall function, mobility, and metabolic regulation. Patients often assume that shedding excess weight will relieve joint pain, especially in the knees. But many are surprised to find that, after losing weight, their knee pain actually worsens.

Why? Because losing muscle weakens the support structures around the knee. Your glutes, quads, and hamstrings are responsible for stabilizing the knee joint. When these muscles shrink, your knees take on more stress, leading to instability, discomfort, and even increased risk of injury. This is why some people, despite losing significant weight, feel weaker, less mobile, and more prone to pain.


Combating Muscle Loss with Strength Training and EMSCULPT

To counteract this muscle loss, it's crucial to incorporate muscle-building activities into your routine. One of the solutions I’ve introduced in my practice is EMSCULPT, a treatment that helps build muscle through high-intensity contractions. A 30-minute session produces 20,000 super-maximal contractions, strengthening key muscle groups like the glutes, quads, and hamstrings. All of these muscle groups play a vital role in knee stability.

Beyond clinical treatments, resistance training is non-negotiable for anyone using GLP-1 medications. In fact, some healthcare providers are now requiring patients to commit to strength training before prescribing these drugs. But not just any workout will do. To effectively build muscle, workouts need to be intense. You should be lifting heavy enough to challenge the muscles, reaching near-failure with 8-12 reps per set, and allowing proper rest and recovery between sessions. Ideally, full-body strength training twice a week can help preserve and even rebuild lost muscle.


The Long-Term Dangers of Muscle Loss and How to Prevent Them

Neglecting muscle maintenance can have serious long-term consequences. Losing muscle leads to reduced bone density, which increases the risk of osteoporosis and fractures. Women, in particular, are at high risk. 70% of hip fractures occur in women and one in four will die within a year of breaking a hip.

Additionally, muscle plays a key role in insulin sensitivity. If muscle loss is not addressed, stopping GLP-1 medications can increase the risk of diabetes relapse, cardiovascular disease, and overall mortality. In fact, research shows that 85% of GLP-1 users stop the medication within two years, often regaining weight, primarily as fat instead of muscle. This shift in body composition further raises the risk of metabolic disorders and makes future weight management even harder.


Final Thoughts

If you’re using or considering GLP-1 medication, muscle loss is a real concern, but it’s not inevitable. By incorporating strength training, muscle-building therapies like EMSCULPT, and proper nutrition, you can protect your lean mass, reduce knee pain, and maintain metabolic health. The goal isn't just weight loss, it’s long-term strength, mobility, and vitality.

Let’s prioritize muscle, not just weight loss, and set ourselves up for a healthier, stronger future.


If you're ready to take control of your knee pain, click here to discover more about these five effective knee pain home treatments. With these simple steps, you can start your journey towards pain-free knees and a more active lifestyle.

Tammy Penhollow, DO, is an experienced pain management and regenerative medicine specialist practicing at Precision Regenerative Medicine, located in Scottsdale, Arizona. She is skilled in image-guided joint and spine injections and regenerative aesthetic procedures. 

Dr. Penhollow graduated from Kirksville College of Osteopathic Medicine (now known as AT Still University). She completed her transitional year internship at Sacred Heart Medical Center in Spokane, Washington, and began her US Navy career deployed to Kosovo as the solo physician for a 720 person US Naval Mobile Construction Battalion.
Following that, she completed a second General Medical Officer assignment for three years as an instructor for the Navy’s Independent Duty Corpsman school, where she taught physical diagnosis and medical diagnosis and treatment to the Navy’s advanced corpsmen who were assigned to forward deployed marine units, submarines and special forces units.

Dr. Tammy Penhollow

Tammy Penhollow, DO, is an experienced pain management and regenerative medicine specialist practicing at Precision Regenerative Medicine, located in Scottsdale, Arizona. She is skilled in image-guided joint and spine injections and regenerative aesthetic procedures. Dr. Penhollow graduated from Kirksville College of Osteopathic Medicine (now known as AT Still University). She completed her transitional year internship at Sacred Heart Medical Center in Spokane, Washington, and began her US Navy career deployed to Kosovo as the solo physician for a 720 person US Naval Mobile Construction Battalion. Following that, she completed a second General Medical Officer assignment for three years as an instructor for the Navy’s Independent Duty Corpsman school, where she taught physical diagnosis and medical diagnosis and treatment to the Navy’s advanced corpsmen who were assigned to forward deployed marine units, submarines and special forces units.

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